Data from CIMA-Q
The CIMA-Q Biological and Data Bank is a structured collection of results from clinical, neuropsychological and neuropsychiatric tests and evaluations, as well as biological samples from adults in good health or with impaired cognition (eg, subjective cognitive impairment, mild cognitive impairment, Alzheimer’s disease). These data, results and samples were obtained within the framework of research projects carried out by members of CIMA-Q and their collaborators.
Quick downloads
Official data from data_release_13 March 2023
How can I access the CIMA-Q data
01. | First you have to be a Consortium for the Early Identification of Alzheimer’s Disease – Quebec member. Form to apply for a membership. |
02. | To access the CIMA-Q Bank, please ensure that you have your ethics approval letter for the research project. If your project has not been approved to date you must submit it to the Ageing and Neuroimaging Research Ethics Board (VN REB) for approval (https://criugm.qc.ca/la-recherche/comite-dethique-de-la-recherche/). The ethics approval number must be provided to the databank manager in order to access the LORIS platform. |
03. | Appendix K: Complete the form describing the research project for which you intend to request access. Attach all relevant supporting documents to your application (see list at the end of Appendix K). The User Agreement(s) must be completed and signed by the principal investigator and the administrative representative of the investigator’s institution. Appendices B1 and B3 must be provided for all access applications whereas Appendix B2 must be provided only for biological material access applications. |
04. | Submit your documents to the User Access Committee (UAC) at: cimaq@criugm.qc.ca or directly to the Interim UAC Manager, Ms. France-Hélène Joncas |
05. | Evaluation of your application by the UAC (evaluation within one week of receiving the complete file). One of the three following statuses might be issued by the UAC following your application:
If your application is accepted with conditions, you will have to respond to the UAC’s requests. Please submit to the following address: France-Helene.Joncas@crchudequebec.ulaval.ca |
06. | Issuance of the final approval letter for access to the CIMA-Q Data and Biomaterial Bank by the Executive Committee once the user agreements have been signed by the CIUSSS CS MTL administrative manager who oversees the CIMA-Q project. |
07. | Access: To Access: CLINICAL / SOCIO-DEMOGRAPHIC / BIOLOGICAL / NEUROPSYCHOLOGICAL / IMAGING DATA Contact the LORIS platform manager who will grant you access codes to access the data: pierre-emmanuel.morin.ccsmtl@ssss.gouv.qc.ca To access: BIOMATERIAL Please note: biological material is reserved for Quebec members only. If you are outside of Quebec, please inquire about the possibility of collaborating with a Quebec researcher. |

As of July 2023:
PARTICIPANTS: 400 +
M :37 % F: 63 %
Controls: 18%
Subjective Cognitive Decline: 44 %
Mild Cognitive Impairment: 29 %
Alzheimer’s Disease (early): 9 %
FULL ASSESSMENT
(CLINICAL + NEUROPSY.)
Initial assessments: 400 + (225+ MRI)
Post-2 year assessments: 211 (106 MRI)
Post-4 year assessments:149 (52 MRI)
Post-6 year assessments: 104 + (59 MRI)
Post-8 year assessments: 14 (7 MRI)
Total Clinical + Neuropsy. + blood: 878
Total MRI: 449
Total PET scans: 29
BIOSAMPLES
Blood 19 000+
CSF (60 participants) 6000+
CSF young controls: to come
BRAIN BANK: 3
All Data and Biomaterial available in the CIMA-Q bank
CLINICAL ASSESSMENT
NURSE AND MEDICAL DOCTOR ASSESSMENT
- Telephone-Mini Mental State Examination
- Socio-demographic information
- Logical Memory test from the Wechsler Memory Scale (short story, immediate and delayed recall)
- Cognitive reserve questionnaire (Bartrés score)
- Self-perception of health and smoking
- Health status – measurements (vital signs)
- Walking speed
- Grip strength
- Mini Nutritional Assessment® SF
- Allergies
- List of current medications
- Questions relating to sleep disorders
- Alzheimer’s disease cooperative study (ADCS) – Activities of
Daily Living questionnaire - PHQ-9 (Patient Health Questionnaire)
- MoCA (Montreal Cognitive Assessment)
- Medical history
- Physical examination
- Neurological examination
- Neuropsychiatric Inventory (NPI-Q)
- Score – Clinical Dementia Rating (CDR)
- Hachinski Ischemic Scale
- Clinical diagnosis
- Clinical inclusion/exclusion criteria
- Mild Behavioral Impairment Checklist (MBI-C)
- Gender identity
- Smell identification test (UPSIT)
- Biochemistry profile
- Hematology profile
- Anxiety vs COVID-19
HOME QUESTIONNAIRES
- Geriatric Depression Scale (GDS-30)
- Cognitive Change Index (CCI)
- Memory Self-Evaluation (QAM, short form)
- Geriatric Anxiety Inventory (GAI)
- Epworth Sleepiness Scale (Epworth)
- Insomnia Severity Index (ISI)
- Questions on bilingualism
- Chronic pain Self-Assessment
- Technology experience profile
- Mobile Device Proficiency
- Short Form health and well-being survey (SF-36)
- Perception Regarding Investigational Screening for Memory in Primary Care
- Dementia Attitude Scale (DAS)
- Knowledge about Alzheimer’s disease
- Siegrist’s Questionnaire (effort-reward imbalance)
- Karasek’s Questionnaire (Work and professional relationships)
STUDY PARTNER QUESTIONNAIRES
- Cognitive complaint question (Jessen)
- Neuropsychiatric Inventory (NPI-Q),
- Apathy Inventory (AI)
- Questionnaire relating to activities of daily living (ADCS-PI)
- Mild Behavioral Impairment Checklist (MBI-C)
NEUROPSYCHOLOGICAL ASSESSMENT
MEMORY
- 15 Word list / episodic memory (Rey Auditory Verbal Learning Task, RAVLT)
- Envelope Task (prospective memory)
- Face-Name memory test (associative episodic memory)
- Cued recall from Memoria (episodic memory)
PERCEPTION
- Object Decision test / Birmingham Object Recognition Battery (BORB)
- Visual Perception line orientation test (BORB)
EXECUTIVE FUNCTIONS
- Stroop-D-KEFS (4 conditions)
- Trail making test A and B
- Computerized Hayling task
- Digit Symbol test from the WAIS-III
- Alpha-span (short version)
LANGUAGE
- Verbal fluency (category – animals)
- Boston Naming Test
- Vocabulary test (WAIS-III)
PSYCHIATRIC SX and SLEEP
- Apathy Inventory questionnaire
- Questions on sleep habits
MRI ASSESSMENT
ANATOMICAL 3DT1w | |
PATHOLOGICAL PD and T2w | |
VASCULAR Flair and T2* | |
CONNECTIVITY / FUNCTIONAL
| |
And PET SCANS |
BLOOD BIOSAMPLES
- Plasma
- Serum
- Red blood cells
- PBMCs / iPSC / iPSC-derived neurons
- DNA / Buffy coat
- RNA
RESULTS:
- p-Tau 181 / p-Tau 231
- Apo E genotype
CSF BIOSAMPLES (60 participants)
RESULTS:
- Aβ40 / Aβ42 / Aβ38
- Total Tau